| Title | Genre | Platform | Last Updated |
|---|---|---|---|
| Sam Suede: Undercover Exposure | Action/Adventure | psp | May 16, 2006 |
| Samurai Warriors: State of War | Tactical Action | psp | February 16, 2006 |
| Scarface: Money. Power. Respect | Strategy | psp | July 28, 2006 |
| Secret Agent Clank | Action Platformer | psp | May 2, 2008 |
| SEGA Genesis Collection | Compilation | psp | September 22, 2006 |
| SEGA Rally Revo | Racing | psp | September 22, 2007 |
| Sense Me | Music | psp | September 27, 2009 |
| Shaun White Snowboarding | Extreme Sports | psp | September 23, 2008 |
| Shin Megami Tensei: Persona | Role-Playing | psp | June 21, 2009 |
| Shrek the Third | Action Platformer | psp | May 21, 2007 |
| Sid Meier's Pirates! | Adventure | psp | January 23, 2007 |
| Silent Hill Origins | Horror | psp | May 31, 2007 |
| Silent Hill: Shattered Memories | Survival Horror | psp | March 7, 2010 |
| Sky Force | Shooter | psp | January 5, 2011 |
| Smart Bomb | Puzzle | psp | September 16, 2005 |
